Robert Salvayre Selected Research

GW 4869

1/2018	nSMase2 (Type 2-Neutral Sphingomyelinase) Deficiency or Inhibition by GW4869 Reduces Inflammation and Atherosclerosis in Apoe-/- Mice.
1/2015	Hyaluronan synthase-2 upregulation protects smpd3-deficient fibroblasts against cell death induced by nutrient deprivation, but not against apoptosis evoked by oxidized LDL.
12/2011	A key role for matrix metalloproteinases and neutral sphingomyelinase-2 in transplant vasculopathy triggered by anti-HLA antibody.

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Robert Salvayre Research Topics

Disease

25	Atherosclerosis 01/2020 - 12/2002
8	Inflammation (Inflammations) 01/2018 - 08/2003
5	Rupture 08/2009 - 04/2003
4	Pre-Eclampsia (Preeclampsia) 01/2021 - 01/2019
4	Neoplasms (Cancer) 01/2017 - 01/2005
3	Hypercholesterolemia 01/2020 - 01/2003
3	Heart Failure 08/2017 - 02/2007
3	Muscular Diseases (Myopathy) 06/2008 - 01/2007
3	Necrosis 03/2005 - 12/2002
2	Atherosclerotic Plaque (Atheroma) 10/2017 - 12/2002
2	Cardiovascular Diseases (Cardiovascular Disease) 03/2016 - 02/2010
2	Hyperglycemia 12/2009 - 05/2002
2	Ichthyosis (Xeroderma) 06/2007 - 01/2007
2	Carcinoma (Carcinomatosis) 01/2005 - 09/2004
2	Thrombosis (Thrombus) 06/2004 - 04/2003
1	Hypoxia (Hypoxemia) 01/2021
1	Fetal Growth Retardation (Intrauterine Growth Retardation) 01/2021
1	Wounds and Injuries (Trauma) 01/2019
1	Type A Niemann-Pick Disease 01/2018
1	Vascular Remodeling 01/2017
1	Coronary Disease (Coronary Heart Disease) 01/2017
1	Colonic Neoplasms (Colon Cancer) 09/2015
1	Colorectal Neoplasms (Colorectal Cancer) 09/2015
1	Starvation 01/2015
1	Pathologic Processes 11/2013
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 11/2013
1	Septic Shock (Toxic Shock Syndrome) 11/2013
1	Anorexia Nervosa 06/2012
1	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 12/2011
1	Acute Coronary Syndrome 02/2010
1	Coronary Artery Disease (Coronary Atherosclerosis) 02/2010
1	Sepsis (Septicemia) 03/2009
1	Hyperplasia 02/2009
1	Carcinogenesis 09/2008
1	Infections 05/2008
1	Liver Cirrhosis (Hepatic Cirrhosis) 05/2008
1	Alcoholic Liver Cirrhosis (Alcoholic Cirrhosis) 05/2008
1	Liver Diseases (Liver Disease) 05/2008
1	Alcoholic Liver Diseases (Alcoholic Liver Disease) 05/2008
1	Insulin Resistance 03/2008
1	Hypertriglyceridemia 03/2008

Drug/Important Bio-Agent (IBA)

14	oxidized low density lipoproteinIBA 01/2020 - 12/2002
10	LipidsIBA 01/2017 - 08/2003
9	LDL Lipoproteins (beta Lipoproteins)IBA 01/2020 - 12/2002
8	AntioxidantsIBA 01/2021 - 12/2002
6	Biological ProductsIBA 03/2016 - 12/2002
5	Proteins (Proteins, Gene)FDA Link 10/2017 - 12/2002
4	4-hydroxy-2-nonenal (4-hydroxynonenal)IBA 01/2021 - 12/2002
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2021 - 01/2019
3	Free RadicalsIBA 01/2020 - 02/2007
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2020 - 06/2011
3	Apolipoproteins E (ApoE)IBA 01/2018 - 06/2011
3	GW 4869IBA 01/2018 - 12/2011
3	CeramidesIBA 01/2015 - 09/2004
3	Advanced Glycation End ProductsIBA 12/2009 - 05/2002
2	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 01/2021 - 01/2019
2	Oxygen (Dioxygen)IBA 01/2021 - 01/2020
2	ResveratrolIBA 06/2019 - 07/2009
2	Biomarkers (Surrogate Marker)IBA 08/2017 - 03/2009
2	PowdersIBA 03/2016 - 09/2015
2	Glucose (Dextrose)FDA LinkGeneric 01/2015 - 12/2009
2	Fatty Acids (Saturated Fatty Acids)IBA 11/2013 - 02/2010
2	Phospholipids (Phosphatides)FDA LinkGeneric 11/2013 - 02/2010
2	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 06/2012 - 02/2010
2	SphingomyelinsIBA 03/2010 - 09/2004
2	Plasminogen Activators (Plasminogen Activator)IBA 12/2009 - 01/2005
2	Caveolin 1IBA 08/2009 - 05/2008
2	Cadherins (E-Cadherin)IBA 09/2008 - 01/2005
2	beta CateninIBA 09/2008 - 01/2005
2	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 10/2007 - 01/2007
2	Lipase (Acid Lipase)FDA Link 06/2007 - 01/2007
2	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 04/2007 - 08/2005
2	EnzymesIBA 04/2007 - 03/2005
1	NOC 18IBA 01/2019
1	Growth Factor ReceptorsIBA 10/2017
1	Extracellular Matrix ProteinsIBA 10/2017
1	Cell Cycle ProteinsIBA 10/2017
1	AllantoinIBA 08/2017
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2017
1	Angiogenesis InhibitorsIBA 01/2017
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2017
1	CholesterolIBA 01/2017
1	Pyruvic Acid (Pyruvate)IBA 01/2015
1	Bovine Serum AlbuminIBA 01/2015
1	Hyaluronan SynthasesIBA 01/2015
1	ElastinIBA 01/2015
1	HomocysteineIBA 01/2015
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2015
1	AntibodiesIBA 12/2011
1	HydrazonesIBA 07/2010
1	hydrazine (hydrazine dihydrochloride)IBA 11/2008
1	TCF Transcription FactorsIBA 09/2008
1	CytokinesIBA 05/2008
1	MitogensIBA 05/2008
1	HDL CholesterolIBA 03/2008
1	Insulin (Novolin)FDA Link 03/2008
1	Apolipoprotein A-I (Apolipoprotein A1)IBA 03/2008

Therapy/Procedure

1	Therapeutics 01/2017
1	Nutritional Support (Artificial Feeding) 11/2013
1	Liver Transplantation 05/2008